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Inside susceptible microorganisms, Metronidazole undergoes reductive activation by intracellular electron transport proteins. The resulting reactive intermediates interact with microbial DNA, disrupting its helical structure and causing strand breakage. This leads to inhibition of nucleic acid synthesis and cell death.
Biozyl 400 is active against:
- Most anaerobic protozoa
- Some Gram-positive and Gram-negative bacteria
- Certain facultative anaerobes
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Biozyl 400 is a broad-spectrum antimicrobial agent effective against bacteria and protozoa. It is widely used to treat infections of the respiratory tract, gastrointestinal system, skin, bones, reproductive organs, and oral cavity. Metronidazole — the active component — acts by damaging the DNA of susceptible microorganisms, resulting in the inhibition of protein synthesis and ultimately cell death.
This medicine is particularly effective against anaerobic bacteria and certain protozoal infections.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Biozyl 400 is indicated for the treatment of:
- Pneumonia and aspiration pneumonia
- Peritonitis and intra-abdominal infections
- Septicemia and endocarditis
- Bone and joint infections
- Lung abscess, empyema, and meningitis/brain abscess
- Pelvic infections such as endometritis
- Gastrointestinal infections:
- Amoebiasis
- Giardiasis
- Peptic ulcer disease (H. pylori infection)
- Diverticulitis
- Antibiotic-associated colitis
- Genitourinary infections:
- Trichomoniasis
- Bacterial vaginosis
- Skin and soft tissue infections:
- Leg ulcers, pressure sores, fungating tumors, diabetic foot ulcer
- Oral infections:
- Acute dental infections
- Acute necrotizing ulcerative gingivitis
- Surgical prophylaxis against anaerobic bacterial contamination
✔️ Side Effects
- Headache
- Nausea or vomiting
- Metallic or bitter taste in the mouth
- Dry mouth
✔️ Dosage | Metronidazole
Adult Dosage
| Condition | Recommended Dose | Duration / Notes |
|---|---|---|
| Amoebiasis | 800 mg three times daily | 5 days for intestinal infection; 5–10 days for extra-intestinal infection (Max: 2.4 g/day) |
| Trichomoniasis | 2 g single dose OR 200 mg three times daily for 7 days OR 400 mg twice daily for 5–7 days | Sexual partners should be treated simultaneously. Treatment may be repeated after 4–6 weeks if necessary. |
| Giardiasis | 2 g once daily for 3 days OR 400 mg three times daily for 5 days OR 500 mg twice daily for 7–10 days | — |
| Bacterial vaginosis | 2 g single dose OR 400 mg twice daily for 5–7 days | — |
| Acute necrotising ulcerative gingivitis | 200 mg three times daily | For 3 days |
| Anaerobic bacterial infections | Initial: 800 mg, followed by 400 mg every 8 hours OR 7.5 mg/kg every 6–8 hours (Max: 4 g/day) | Duration usually 7 days depending on severity |
| Prophylaxis (Postoperative anaerobic infections) | 400 mg every 8 hours, starting 24 hours before surgery | Continue with IV or rectal route postoperatively until oral therapy can resume |
| H. pylori eradication (Peptic ulcer) | 400 mg twice daily with another antibiotic and a PPI (or 400 mg three times daily with omeprazole + amoxicillin) | For 1 week |
| Leg ulcers / Pressure sores | 400 mg three times daily | For 7 days |
| Acute dental infections | 200 mg three times daily | For 3–7 days |
| Anaerobic infections (IV) | 500 mg infused in 100 mL (5 mg/mL) at 5 mL/min every 8 hours OR 15 mg/kg over 1 hr followed by 7.5 mg/kg over 1 hr every 6 hr | Max: 4 g/day; switch to oral therapy ASAP |
| Postoperative prophylaxis (IV) | 500 mg shortly before surgery and repeated every 8 hr OR 15 mg/kg infused over 30–60 min before operation, then 7.5 mg/kg at 6 and 12 hr after | — |
| Hepatic impairment (severe) | One-third of the usual dose, once daily | Adjust according to clinical response |
Pediatric Dosage
| Condition | Age Group | Recommended Dose | Duration |
|---|---|---|---|
| Amoebiasis | 1–3 years | 100–200 mg three times daily | 5–10 days |
| 3–7 years | 100–200 mg four times daily | 5–10 days | |
| 7–10 years | 200–400 mg three times daily | 5–10 days | |
| Trichomoniasis | 1–10 years | 40 mg/kg as a single dose OR 15–30 mg/kg/day in 2–3 divided doses (Max: 2 g/dose) | 7 days |
| Giardiasis | 1–3 years | 500 mg once daily | 3 days |
| 3–7 years | 600–800 mg once daily | 3 days | |
| 7–10 years | 1 g once daily | 3 days | |
| Acute necrotising ulcerative gingivitis | 1–3 years | 50 mg three times daily | 3 days |
| 3–7 years | 100 mg twice daily | 3 days | |
| 7–10 years | 100 mg three times daily | 3 days | |
| Anaerobic bacterial infections | <8 weeks | 7.5 mg/kg every 12 hr or 15 mg/kg once daily | Usually 7 days |
| 8 weeks–12 years | 7.5 mg/kg every 8 hr or 20–30 mg/kg once daily | 7 days (based on severity) | |
| Prophylaxis (Postoperative anaerobic infections) | <40 weeks | 10 mg/kg single dose before surgery | — |
| <12 years | 20–30 mg/kg single dose 1–2 hr before surgery | — | |
| Anaerobic infections (IV) | — | 7.5 mg/kg every 8 hr | — |
✔️ Contraindications:
History of hypersensitivity to metronidazole or other nitroimidazole derivatives. Pregnancy (1st trimester) and lactation.
✔️ Metronidazole Tablets:
Should be taken with food to minimize gastrointestinal discomfort.
✔️ Drug Interactions
- Concurrent use with disulfiram may cause psychotic reactions.
- May enhance the effects of oral anticoagulants, increasing the risk of bleeding.
- Lithium toxicity may occur due to elevated serum lithium levels.
- May reduce renal clearance and increase the toxicity of 5-fluorouracil.
- Can raise serum concentrations of ciclosporin and busulfan, leading to potential toxicity.
- Phenobarbital and phenytoin may enhance the metabolism of metronidazole, lowering its plasma concentration and therapeutic efficacy.
✔️ Precautions
- Use cautiously in patients with CNS disorders or seizure history; discontinue if any neurological abnormalities develop.
- Monitor total and differential leukocyte counts before and after treatment in patients with a history of blood dyscrasias.
- Hepatic impairment: Dose adjustment and plasma monitoring may be necessary in severe cases.
- Contains sodium — exercise caution in patients predisposed to edema.
- Prolonged use may lead to fungal or bacterial superinfections.
- Since metronidazole is excreted in breast milk, its use during lactation is not recommended.
✔️ Storage:
Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
📦Pricing Information, Availability:
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